One-Year Renal Function in Patients with Chronic Renal Failure and Metabolic Syndrome

Abstract

Background: Recently, chronic renal failure (CRF) has increased worldwide. CRF is a major risk factor to end-stage renal diseases. The incidence of metabolic syndrome (MS) and its cardiovascular complications is common in patients CRF, too. In this study, we compared renal function in patients with CRF and with or without metabolic syndrome. Methods: This study was conducted in 2017 among 100 patient with CRF with glomerular filtration rate (GFR) of 15-60 ml/min/1.73m2, 50 patients with and 50 without metabolic syndrome. Metabolic syndrome criteria, as well as serum creatinine were measured in all the patients each 3 months till 1 year. Findings: 42 patients were women and 58 were men. The mean GFR was not significantly different among the patients with or without metabolic syndrome (P = 0.322) in 1-year follow up. In 3-month follow ups, only there was a significant association between systolic blood pressure and GFR with metabolic syndrome (P = 0.028, P = 0.030, P = 0.020, and P = 0.15 in 1st, 2nd, 3rd, and 4th 3-month follow up). In 1-year follow up, there was no significant association between other metabolic syndrome criteria and GFR in patients with metabolic syndrome [P = 0.214, P = 0.061, P = 0.409, P = 0.315, and P = 0.284 for abdominal obesity, diastolic blood pressure, triglyceride, high-density lipoprotein (HDL), and fasting blood sugar (FBS)]. Conclusion: Metabolic syndrome does not any effect on renal function in patients with CRF. We recommend further studies with longer follow-up period.

Keywords

• Metabolic syndrome
• Glomerular filtration rate
• Chronic kidney failure