G82S RAGE polymorphism is associated with Alzheimer’s disease

Abstract

Receptor for advanced glycation end products (RAGE) has been implicated in the pathophysiology of Alzheimer’s disease (AD) due to its ability to interact with amyloid beta and to elicit an inflammatory response. sRAGE, one of the splice variants of RAGE, has been reported to be a decoy receptor for amyloid beta peptides. The present study addresses the occurrence of G82S RAGE polymorphism in AD, and its association with the expression of sRAGE and amyloid beta load (Aβ peptide). The results indicated that the heterozygous genotype (GS) was distributed more than the wild genotype (GG) in patients with AD. Moreover, in patients with AD, there was decreased expression of sRAGE and increased expression of tRAGE and TNF-α. The data show that G82S RAGE polymorphism is highly associated with the development of AD, with decreased expression of sRAGE and increased expression of tRAGE and TNF-α.

Keywords

• amyloid toxicity
• oxidative stress
• rage
• srage
• polymorphism
• ad