Apolipoprotein M (ApoM) involved in the Nile tilapia (Oreochromis niloticus) against Streptococcus agalactiae infection

Xuyan Tan; Yongxiong Huang; Zhiqiang Zhang; Yuhang Dong; Kwaku Amoah; Yu Huang; Jichang Jian

Aquaculture Reports (Dec 2024)

Apolipoprotein M (ApoM) involved in the Nile tilapia (Oreochromis niloticus) against Streptococcus agalactiae infection

Xuyan Tan,
Yongxiong Huang,
Zhiqiang Zhang,
Yuhang Dong,
Kwaku Amoah,
Yu Huang,
Jichang Jian

Affiliations

Xuyan Tan: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China
Yongxiong Huang: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China
Zhiqiang Zhang: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China
Yuhang Dong: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China
Kwaku Amoah: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China
Yu Huang: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China; Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, China; Corresponding authors at: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China.
Jichang Jian: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China; Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, China; Corresponding authors at: Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang 524088, China.

Journal volume & issue: Vol. 39
p. 102506

Abstract

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Apolipoprotein M (ApoM) is a type of apolipoprotein in the bloodstream, with a primary affinity for high-density lipoprotein (HDL). It exhibits tissue-specific expression and performs a variety of biological functions, including lipid transport and metabolism, as well as antibacterial and anti-inflammatory effects. In order to elucidate the immune mechanism of ApoM in fish, we initiated the cloning of the ApoM gene in the widely studied Nile tilapia (Oreochromis niloticus) (On-ApoM) and examined its role during acute bacterial infection. The open reading frame (ORF) for On-ApoM encompasses 591 bp, encoding a protein of 196 amino acids. Notably, On-ApoM is mainly expressed in the liver of tilapia. After Streptococcus agalactiae stimulation, On-ApoM was activated to varying degrees in the liver, brain, spleen, head kidney, intestine, and other immune tissues of tilapia. While our study revealed that On-ApoM decreased bacterial load in the liver, On-ApoM again demonstrated the ability to inhibit inflammatory processes, consequently enhancing tilapia survival during acute bacterial infection. Alternatively, On-ApoM may play a role in modulating various immune pathways. These findings lay the groundwork for further exploration of the role of On-ApoM in fish immunity.

Published in Aquaculture Reports

ISSN: 2352-5134 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Agriculture: Aquaculture. Fisheries. Angling
Website: http://www.journals.elsevier.com/aquaculture-reports/

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