Nature Communications (Oct 2018)

Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast

  • Marc Larochelle,
  • Marc-Antoine Robert,
  • Jean-Nicolas Hébert,
  • Xiaochuan Liu,
  • Dominick Matteau,
  • Sébastien Rodrigue,
  • Bin Tian,
  • Pierre-Étienne Jacques,
  • François Bachand

DOI
https://doi.org/10.1038/s41467-018-06546-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Termination of RNA polymerase II (RNAPII) transcription is an essential step of gene expression. Here the authors provide evidence that in fission yeast termination of ncRNA genes occurs by a cleavage-dependent mechanism involving recruitment of mRNA 3′ end processing factors and requires the conserved Ysh1/CPSF-73 and Dhp1/XRN2 nucleases.