Influence of ABCB1 genetic polymorphisms on the antiemetic response to ondansetron-based medication for cisplatin-based chemotherapy in South Indian cancer patients in a tertiary care hospital

Porkodi Ayyar; Shewade Deepak Gopal; Charanraj Goud Alladi

doi:10.2478/cipms-2023-0022

Current Issues in Pharmacy and Medical Sciences (Sep 2023)

Influence of ABCB1 genetic polymorphisms on the antiemetic response to ondansetron-based medication for cisplatin-based chemotherapy in South Indian cancer patients in a tertiary care hospital

Porkodi Ayyar,
Shewade Deepak Gopal,
Charanraj Goud Alladi

Affiliations

Porkodi Ayyar: 1Pharmacology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, India
Shewade Deepak Gopal: 2Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), India
Charanraj Goud Alladi: 3Department of Dermatology & STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), India

DOI: https://doi.org/10.2478/cipms-2023-0022
Journal volume & issue: Vol. 36, no. 3
pp. 129 – 135

Abstract

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Genetic variations in the receptor, metabolizing enzymes and transporters may explain a part of the variation in anti-emetic response to ondansetron among cancer patients. This study assesses the role of ABCB1 genetic polymorphisms in the anti-emetic efficacy of ondansetron-based medication for cisplatin-based chemotherapy in South Indian cancer patients.

Published in Current Issues in Pharmacy and Medical Sciences

ISSN: 2084-980X (Print); 2300-6676 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine
Website: https://sciendo.com/journal/CIPMS

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