Nature Communications (Oct 2017)

Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

  • Pedro Vallecillo-García,
  • Mickael Orgeur,
  • Sophie vom Hofe-Schneider,
  • Jürgen Stumm,
  • Verena Kappert,
  • Daniel M. Ibrahim,
  • Stefan T. Börno,
  • Shinichiro Hayashi,
  • Frédéric Relaix,
  • Katrin Hildebrandt,
  • Gerhard Sengle,
  • Manuel Koch,
  • Bernd Timmermann,
  • Giovanna Marazzi,
  • David A. Sassoon,
  • Delphine Duprez,
  • Sigmar Stricker

DOI
https://doi.org/10.1038/s41467-017-01120-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 18

Abstract

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Fibro-adipogenic progenitors (FAPs) form part of interstitial muscle connective tissue (MCT) in adults but the origin of this non-myogenic lineage is unclear. Here, the authors show that Odd skipped related 1 (Osr1) in mice marks embryonic MCT, giving rise to FAPs, and loss of Osr1 in the limb causes muscle defects.