OncoTargets and Therapy (Oct 2020)
The Tumor-Associated Macrophage-M2-Cancer Cell Complex and the Observation of Heterogeneous Modification of the Morphological Structure of Lung Adenocarcinoma
Abstract
Wei-Hua Xiao,1 Li-Ping Yao,2 Min Li,2 Min Wang,1 Liang Wu,2 Mao-Fen Jiang,1 Hai-Fen Ma,1 Jun-Qiang Li,1 Guo-Rong Chen2 1Department of Pathology, Ningbo Beilun People’s Hospital, Ningbo 315800, People’s Republic of China; 2Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People’s Republic of ChinaCorrespondence: Wei-Hua XiaoDepartment of Pathology, Ningbo Beilun People’s Hospital, Ningbo 315800, People’s Republic of ChinaTel +86 0574 8610 0266Fax +86 0574 8677 6335Email [email protected] ChenDepartment of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People’s Republic of ChinaTel/Fax +86 0577 8668 9908Email [email protected]: The aim of this study was to investigate the effect of the tumor-associated macrophage-m2-cancer cell complex (TAM-M2-CC) on the heterostructural modification of lung adenocarcinoma.Methods: The expression of CD163+/CD68+ in macrophages in the microenvironment of 161 cases of lung adenocarcinoma was identified by dual immunohistochemistry, and the association between a TAM-M2-CC and its growth, as well as the histological changes in lung adenocarcinoma cells, was assessed.Results: The morphological change of lung adenocarcinoma was related to the number of m2 phenotypes of the macrophages in the microenvironment of lung adenocarcinoma. TAM-M2-CCs were involved in the process of cancer cell recognition, association, and reconstruction.Conclusion: The microenvironment of lung adenocarcinoma can affect the phenotypic distinction of macrophages, and the polarization recruitment, zombification, and formation of a TAM-M2-CC, which can also affect the local differentiation of lung adenocarcinoma to a certain extent. The applicable pathogenesis needs to be verified and studied further.Keywords: tumor-related macrophage-M2-cancer cell complex, TAM-M2-CC, heterostructural modification, microenvironment of lung adenocarcinoma, phenotypic differentiation, local differentiation