Nature Communications (Jan 2018)

Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

  • Lei Deng,
  • Teena Mohan,
  • Timothy Z. Chang,
  • Gilbert X. Gonzalez,
  • Ye Wang,
  • Young-Man Kwon,
  • Sang-Moo Kang,
  • Richard W. Compans,
  • Julie A. Champion,
  • Bao-Zhong Wang

DOI
https://doi.org/10.1038/s41467-017-02725-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Relatively well conserved domains of influenza A virus (IAV) proteins are potential candidates for the development of a universal IAV vaccine. Here, Deng et al. combine two such conserved antigens (M2e and HA stalk) in a double-layered protein nanoparticle and show that it protects against divergent IAVs in mice.