Nature Communications (Apr 2020)
Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
Abstract
How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.