Metabolites (Mar 2024)

Metformin and the Liver: Unlocking the Full Therapeutic Potential

  • Federica Perazza,
  • Laura Leoni,
  • Santo Colosimo,
  • Alessandra Musio,
  • Giulia Bocedi,
  • Michela D’Avino,
  • Giulio Agnelli,
  • Alba Nicastri,
  • Chiara Rossetti,
  • Federica Sacilotto,
  • Giulio Marchesini,
  • Maria Letizia Petroni,
  • Federico Ravaioli

DOI
https://doi.org/10.3390/metabo14040186
Journal volume & issue
Vol. 14, no. 4
p. 186

Abstract

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Metformin is a highly effective medication for managing type 2 diabetes mellitus. Recent studies have shown that it has significant therapeutic benefits in various organ systems, particularly the liver. Although the effects of metformin on metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis are still being debated, it has positive effects on cirrhosis and anti-tumoral properties, which can help prevent the development of hepatocellular carcinoma. Furthermore, it has been proven to improve insulin resistance and dyslipidaemia, commonly associated with liver diseases. While more studies are needed to fully determine the safety and effectiveness of metformin use in liver diseases, the results are highly promising. Indeed, metformin has a terrific potential for extending its full therapeutic properties beyond its traditional use in managing diabetes.

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