Synthesis and Photophysical Property Studies of the  2,6,8-Triaryl-4-(phenylethynyl)quinazolines

Malose Jack Mphahlele; Hugues Kadem Paumo; Ahmed M. El-Nahas; Morad M. El-Hendawy

doi:10.3390/molecules19010795

Molecules (Jan 2014)

Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines

Malose Jack Mphahlele,
Hugues Kadem Paumo,
Ahmed M. El-Nahas,
Morad M. El-Hendawy

Affiliations

Malose Jack Mphahlele: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa
Hugues Kadem Paumo: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa
Ahmed M. El-Nahas: Chemistry Department, Faculty of Science, El-Menoufia University, Shebin El-Kom 32512, Egypt
Morad M. El-Hendawy: Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

DOI: https://doi.org/10.3390/molecules19010795
Journal volume & issue: Vol. 19, no. 1
pp. 795 – 818

Abstract

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The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic acids occurred without selectivity to afford the corresponding 2,6,8-triaryl-4-(phenylethynyl)quinazolines. The absorption and emission properties of these polysubstituted quinazolines were also determined.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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