Nature Communications (Apr 2021)
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology
- David Baglietto-Vargas,
- Stefania Forner,
- Lena Cai,
- Alessandra C. Martini,
- Laura Trujillo-Estrada,
- Vivek Swarup,
- Marie Minh Thu Nguyen,
- Kelly Do Huynh,
- Dominic I. Javonillo,
- Kristine Minh Tran,
- Jimmy Phan,
- Shan Jiang,
- Enikö A. Kramár,
- Cristina Nuñez-Diaz,
- Gabriela Balderrama-Gutierrez,
- Franklin Garcia,
- Jessica Childs,
- Carlos J. Rodriguez-Ortiz,
- Juan Antonio Garcia-Leon,
- Masashi Kitazawa,
- Mohammad Shahnawaz,
- Dina P. Matheos,
- Xinyi Ma,
- Celia Da Cunha,
- Ken C. Walls,
- Rahasson R. Ager,
- Claudio Soto,
- Antonia Gutierrez,
- Ines Moreno-Gonzalez,
- Ali Mortazavi,
- Andrea J. Tenner,
- Grant R. MacGregor,
- Marcelo Wood,
- Kim N. Green,
- Frank M. LaFerla
Affiliations
- David Baglietto-Vargas
- Institute for Memory Impairments and Neurological Disorders, University of California
- Stefania Forner
- Institute for Memory Impairments and Neurological Disorders, University of California
- Lena Cai
- Institute for Memory Impairments and Neurological Disorders, University of California
- Alessandra C. Martini
- Institute for Memory Impairments and Neurological Disorders, University of California
- Laura Trujillo-Estrada
- Institute for Memory Impairments and Neurological Disorders, University of California
- Vivek Swarup
- Institute for Memory Impairments and Neurological Disorders, University of California
- Marie Minh Thu Nguyen
- Institute for Memory Impairments and Neurological Disorders, University of California
- Kelly Do Huynh
- Institute for Memory Impairments and Neurological Disorders, University of California
- Dominic I. Javonillo
- Institute for Memory Impairments and Neurological Disorders, University of California
- Kristine Minh Tran
- Institute for Memory Impairments and Neurological Disorders, University of California
- Jimmy Phan
- Institute for Memory Impairments and Neurological Disorders, University of California
- Shan Jiang
- Department of Developmental and Cell Biology, University of California
- Enikö A. Kramár
- Institute for Memory Impairments and Neurological Disorders, University of California
- Cristina Nuñez-Diaz
- Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga
- Gabriela Balderrama-Gutierrez
- Department of Developmental and Cell Biology, University of California
- Franklin Garcia
- Institute for Memory Impairments and Neurological Disorders, University of California
- Jessica Childs
- Institute for Memory Impairments and Neurological Disorders, University of California
- Carlos J. Rodriguez-Ortiz
- Institute for Memory Impairments and Neurological Disorders, University of California
- Juan Antonio Garcia-Leon
- Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga
- Masashi Kitazawa
- Institute for Memory Impairments and Neurological Disorders, University of California
- Mohammad Shahnawaz
- The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston
- Dina P. Matheos
- Institute for Memory Impairments and Neurological Disorders, University of California
- Xinyi Ma
- Department of Developmental and Cell Biology, University of California
- Celia Da Cunha
- Institute for Memory Impairments and Neurological Disorders, University of California
- Ken C. Walls
- Institute for Memory Impairments and Neurological Disorders, University of California
- Rahasson R. Ager
- Institute for Memory Impairments and Neurological Disorders, University of California
- Claudio Soto
- The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston
- Antonia Gutierrez
- Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga
- Ines Moreno-Gonzalez
- Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga
- Ali Mortazavi
- Department of Developmental and Cell Biology, University of California
- Andrea J. Tenner
- Institute for Memory Impairments and Neurological Disorders, University of California
- Grant R. MacGregor
- Department of Developmental and Cell Biology, University of California
- Marcelo Wood
- Institute for Memory Impairments and Neurological Disorders, University of California
- Kim N. Green
- Institute for Memory Impairments and Neurological Disorders, University of California
- Frank M. LaFerla
- Institute for Memory Impairments and Neurological Disorders, University of California
- DOI
- https://doi.org/10.1038/s41467-021-22624-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some aspects of sporadic late onset AD.
