Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians

Lily L. Wong; Christina G. Bruxvoort; Nicholas I. Cejda; Matthew R. Delaney; Jannette Rodriguez Otero; David J. Forsthoefel

doi:10.1038/s41467-022-31385-2

Nature Communications (Jul 2022)

Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians

Lily L. Wong,
Christina G. Bruxvoort,
Nicholas I. Cejda,
Matthew R. Delaney,
Jannette Rodriguez Otero,
David J. Forsthoefel

Affiliations

Lily L. Wong: Genes and Human Disease Research Program, Oklahoma Medical Research Foundation
Christina G. Bruxvoort: Genes and Human Disease Research Program, Oklahoma Medical Research Foundation
Nicholas I. Cejda: Genes and Human Disease Research Program, Oklahoma Medical Research Foundation
Matthew R. Delaney: Genes and Human Disease Research Program, Oklahoma Medical Research Foundation
Jannette Rodriguez Otero: Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign
David J. Forsthoefel: Genes and Human Disease Research Program, Oklahoma Medical Research Foundation

DOI: https://doi.org/10.1038/s41467-022-31385-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

Read online

Lipid metabolism regulates stem cell states and differentiation. Here, the authors demonstrate a requirement in planarians for Apolipoprotein B-mediated neutral lipid transport from intestinal stores to stem cells and their progeny during differentiation and whole-body regeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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