Molecules (Oct 2013)

Schiff Bases: A Short Survey on an Evergreen Chemistry Tool

  • Mauro Panunzio,
  • Stefano Biondi,
  • Wenling Qin,
  • Sha Long

DOI
https://doi.org/10.3390/molecules181012264
Journal volume & issue
Vol. 18, no. 10
pp. 12264 – 12289

Abstract

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The review reports a short biography of the Italian naturalized chemist Hugo Schiff and an outline on the synthesis and use of his most popular discovery: the imines, very well known and popular as Schiff Bases. Recent developments on their “metallo-imines” variants have been described. The applications of Schiff bases in organic synthesis as partner in Staudinger and hetero Diels-Alder reactions, as “privileged” ligands in the organometallic complexes and as biological active Schiff intermediates/targets have been reported as well.

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