Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

Amit K. Gandhi; Zhen-Yu J. Sun; Walter M. Kim; Yu-Hwa Huang; Yasuyuki Kondo; Daniel A. Bonsor; Eric J. Sundberg; Gerhard Wagner; Vijay K. Kuchroo; Gregory A. Petsko; Richard S. Blumberg

doi:10.1038/s42003-021-01871-2

Communications Biology (Mar 2021)

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

Amit K. Gandhi,
Zhen-Yu J. Sun,
Walter M. Kim,
Yu-Hwa Huang,
Yasuyuki Kondo,
Daniel A. Bonsor,
Eric J. Sundberg,
Gerhard Wagner,
Vijay K. Kuchroo,
Gregory A. Petsko,
Richard S. Blumberg

Affiliations

Amit K. Gandhi: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Zhen-Yu J. Sun: Department of Cancer Biology, Dana-Farber Cancer Institute
Walter M. Kim: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Yu-Hwa Huang: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Yasuyuki Kondo: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Daniel A. Bonsor: Institute of Human Virology, University of Maryland School of Medicine, University of Maryland
Eric J. Sundberg: Institute of Human Virology, University of Maryland School of Medicine, University of Maryland
Gerhard Wagner: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Vijay K. Kuchroo: Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital
Gregory A. Petsko: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
Richard S. Blumberg: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s42003-021-01871-2
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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To understand how hCEACAM1 transitions between monomeric and dimeric states that are required for its activity, Gandhi et al. investigate hCEACAM1 homodimeric, monomeric, and transition states and their behavior in solution. This study suggests the flexibility of the GFCC’ face and its role in governing the formation of hCEACAM1 dimers and selective heterodimers.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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