Nature Communications (Nov 2022)
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia
- Lucie Bernard-Raichon,
- Mericien Venzon,
- Jon Klein,
- Jordan E. Axelrad,
- Chenzhen Zhang,
- Alexis P. Sullivan,
- Grant A. Hussey,
- Arnau Casanovas-Massana,
- Maria G. Noval,
- Ana M. Valero-Jimenez,
- Juan Gago,
- Gregory Putzel,
- Alejandro Pironti,
- Evan Wilder,
- Yale IMPACT Research Team,
- Lorna E. Thorpe,
- Dan R. Littman,
- Meike Dittmann,
- Kenneth A. Stapleford,
- Bo Shopsin,
- Victor J. Torres,
- Albert I. Ko,
- Akiko Iwasaki,
- Ken Cadwell,
- Jonas Schluter
Affiliations
- Lucie Bernard-Raichon
- Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine
- Mericien Venzon
- Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine
- Jon Klein
- Department of Immunobiology, Yale School of Medicine
- Jordan E. Axelrad
- Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine
- Chenzhen Zhang
- Institute for Systems Genetics, New York University Grossman School of Medicine
- Alexis P. Sullivan
- Institute for Systems Genetics, New York University Grossman School of Medicine
- Grant A. Hussey
- Institute for Systems Genetics, New York University Grossman School of Medicine
- Arnau Casanovas-Massana
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Maria G. Noval
- Department of Microbiology, New York University Grossman School of Medicine
- Ana M. Valero-Jimenez
- Department of Microbiology, New York University Grossman School of Medicine
- Juan Gago
- Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine
- Gregory Putzel
- Department of Microbiology, New York University Grossman School of Medicine
- Alejandro Pironti
- Department of Microbiology, New York University Grossman School of Medicine
- Evan Wilder
- Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine
- Yale IMPACT Research Team
- Lorna E. Thorpe
- Department of Population Health, New York University Grossman School of Medicine
- Dan R. Littman
- Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine
- Meike Dittmann
- Department of Microbiology, New York University Grossman School of Medicine
- Kenneth A. Stapleford
- Department of Microbiology, New York University Grossman School of Medicine
- Bo Shopsin
- Department of Microbiology, New York University Grossman School of Medicine
- Victor J. Torres
- Department of Microbiology, New York University Grossman School of Medicine
- Albert I. Ko
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Akiko Iwasaki
- Department of Immunobiology, Yale School of Medicine
- Ken Cadwell
- Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine
- Jonas Schluter
- Institute for Systems Genetics, New York University Grossman School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33395-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in COVID-19 patients with blood stream infections, matching reads of bacterial sequences from stool samples to organisms found in the blood.
