Nature Communications (Aug 2022)
Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health
- Danni A. Gadd,
- Robert F. Hillary,
- Daniel L. McCartney,
- Liu Shi,
- Aleks Stolicyn,
- Neil A. Robertson,
- Rosie M. Walker,
- Robert I. McGeachan,
- Archie Campbell,
- Shen Xueyi,
- Miruna C. Barbu,
- Claire Green,
- Stewart W. Morris,
- Mathew A. Harris,
- Ellen V. Backhouse,
- Joanna M. Wardlaw,
- J. Douglas Steele,
- Diego A. Oyarzún,
- Graciela Muniz-Terrera,
- Craig Ritchie,
- Alejo Nevado-Holgado,
- Tamir Chandra,
- Caroline Hayward,
- Kathryn L. Evans,
- David J. Porteous,
- Simon R. Cox,
- Heather C. Whalley,
- Andrew M. McIntosh,
- Riccardo E. Marioni
Affiliations
- Danni A. Gadd
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Robert F. Hillary
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Daniel L. McCartney
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Liu Shi
- Department of Psychiatry, University of Oxford
- Aleks Stolicyn
- Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
- Neil A. Robertson
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh
- Rosie M. Walker
- Centre for Clinical Brain Sciences, Chancellor’s Building
- Robert I. McGeachan
- Centre for Discovery Brain Sciences, University of Edinburgh
- Archie Campbell
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Shen Xueyi
- Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
- Miruna C. Barbu
- Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
- Claire Green
- Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
- Stewart W. Morris
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Mathew A. Harris
- Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
- Ellen V. Backhouse
- Centre for Clinical Brain Sciences, Chancellor’s Building
- Joanna M. Wardlaw
- Centre for Clinical Brain Sciences, Chancellor’s Building
- J. Douglas Steele
- Division of Imaging Science and Technology, Medical School, University of Dundee
- Diego A. Oyarzún
- School of Informatics, University of Edinburgh
- Graciela Muniz-Terrera
- Centre for Clinical Brain Sciences, Edinburgh Dementia Prevention, University of Edinburgh
- Craig Ritchie
- Centre for Clinical Brain Sciences, Edinburgh Dementia Prevention, University of Edinburgh
- Alejo Nevado-Holgado
- Department of Psychiatry, University of Oxford
- Tamir Chandra
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh
- Caroline Hayward
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Kathryn L. Evans
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- David J. Porteous
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Simon R. Cox
- Lothian Birth Cohorts, University of Edinburgh
- Heather C. Whalley
- Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
- Andrew M. McIntosh
- Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
- Riccardo E. Marioni
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-022-32319-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differences that associate with these protein markers.
