ZZ-dependent regulation of p62/SQSTM1 in autophagy

Yi Zhang; Su Ran Mun; Juan F. Linares; JaeWoo Ahn; Christina G. Towers; Chang Hoon Ji; Brent E. Fitzwalter; Michael R. Holden; Wenyi Mi; Xiaobing Shi; Jorge Moscat; Andrew Thorburn; Maria T. Diaz-Meco; Yong Tae Kwon; Tatiana G. Kutateladze

doi:10.1038/s41467-018-06878-8

Nature Communications (Oct 2018)

ZZ-dependent regulation of p62/SQSTM1 in autophagy

Yi Zhang,
Su Ran Mun,
Juan F. Linares,
JaeWoo Ahn,
Christina G. Towers,
Chang Hoon Ji,
Brent E. Fitzwalter,
Michael R. Holden,
Wenyi Mi,
Xiaobing Shi,
Jorge Moscat,
Andrew Thorburn,
Maria T. Diaz-Meco,
Yong Tae Kwon,
Tatiana G. Kutateladze

Affiliations

Yi Zhang: Department of Pharmacology, University of Colorado School of Medicine
Su Ran Mun: Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
Juan F. Linares: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
JaeWoo Ahn: Department of Pharmacology, University of Colorado School of Medicine
Christina G. Towers: Department of Pharmacology, University of Colorado School of Medicine
Chang Hoon Ji: Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
Brent E. Fitzwalter: Department of Pharmacology, University of Colorado School of Medicine
Michael R. Holden: Department of Pharmacology, University of Colorado School of Medicine
Wenyi Mi: Center for Epigenetics, Van Andel Research Institute
Xiaobing Shi: Center for Epigenetics, Van Andel Research Institute
Jorge Moscat: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
Andrew Thorburn: Department of Pharmacology, University of Colorado School of Medicine
Maria T. Diaz-Meco: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
Yong Tae Kwon: Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
Tatiana G. Kutateladze: Department of Pharmacology, University of Colorado School of Medicine

DOI: https://doi.org/10.1038/s41467-018-06878-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerization and macroautophagy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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