A New Butanolide Compound from the Aerial Part of <em>Lindera akoensis</em> with Anti-inflammatory Activity

Abstract

A new butanolide, 3b-((<em>E</em>)-dodec-1-enyl)-4b-hydroxy-5b-methyldihydrofuran-2-one (<strong>1</strong>) and four known butanolides: Akolactone A (<strong>2</strong>), (3<em>Z</em>,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (<strong>3</strong>), (3<em>E</em>,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (<strong>4</strong>) and dihydroisoobtusilactone (<strong>5</strong>), were isolated from the aerial parts of <em>Lindera akoensis.</em> These butanolides showed <em>in vitro</em> anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC₅₀ values of 1.4–179.9 mM.

Keywords

• Chinese medicinal herbs
• &lt;em&gt; Lindera akoensis&lt;/em&gt;
• &lt;em&gt; &lt;/em&gt;butanolide
• anti-inflammatory