Nature Communications (Aug 2017)

HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells

  • Wen-Fang Wang,
  • Li Yan,
  • Zhao Liu,
  • Lan-Xuan Liu,
  • Jian Lin,
  • Zhi-Yin Liu,
  • Xiong-Ping Chen,
  • Wu Zhang,
  • Zi-Zhen Xu,
  • Ting Shi,
  • Jun-Min Li,
  • Yi-Lei Zhao,
  • Guoyu Meng,
  • Yi Xia,
  • Jian-Yong Li,
  • Jiang Zhu

DOI
https://doi.org/10.1038/s41467-017-00476-w
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas.