Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

Reihaneh Haghniaz; Han-Jun Kim; Hossein Montazerian; Avijit Baidya; Maryam Tavafoghi; Yi Chen; Yangzhi Zhu; Solmaz Karamikamkar; Amir Sheikhi; Ali Khademhosseini

Bioactive Materials (May 2023)

Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

Reihaneh Haghniaz,
Han-Jun Kim,
Hossein Montazerian,
Avijit Baidya,
Maryam Tavafoghi,
Yi Chen,
Yangzhi Zhu,
Solmaz Karamikamkar,
Amir Sheikhi,
Ali Khademhosseini

Affiliations

Reihaneh Haghniaz: Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, United States
Han-Jun Kim: California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, United States
Hossein Montazerian: Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, United States
Avijit Baidya: California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States
Maryam Tavafoghi: Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States
Yi Chen: Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, United States
Yangzhi Zhu: Terasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, United States
Solmaz Karamikamkar: Terasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, United States
Amir Sheikhi: Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States; Corresponding authors. Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States.
Ali Khademhosseini: Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, United States; Corresponding authors. Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, United States.

Journal volume & issue: Vol. 23
pp. 314 – 327

Abstract

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Blood loss by hemorrhaging wounds accounts for over one-third of ∼5 million trauma fatalities worldwide every year. If not controlled in a timely manner, exsanguination can take lives within a few minutes. Developing new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical need. Here, biocompatible, and biodegradable microneedle arrays (MNAs) based on gelatin methacryloyl (GelMA) biomaterial hybridized with silicate nanoplatelets (SNs) are developed for hemorrhage control. The SNs render the MNAs hemostatic, while the needle-shaped structure increases the contact area with blood, synergistically accelerating the clotting time from 11.5 min to 1.3 min in vitro. The engineered MNAs reduce bleeding by ∼92% compared with the untreated injury group in a rat liver bleeding model. SN-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat in vivo via combining micro- and nanoengineered features. Furthermore, the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure applications. These hemostatic MNAs may enable rapid hemorrhage control, particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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