NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

Iva Hafner-Bratkovič; Petra Sušjan; Duško Lainšček; Ana Tapia-Abellán; Kosta Cerović; Lucija Kadunc; Diego Angosto-Bazarra; Pablo Pelegrin; Roman Jerala

doi:10.1038/s41467-018-07573-4

Nature Communications (Dec 2018)

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

Iva Hafner-Bratkovič,
Petra Sušjan,
Duško Lainšček,
Ana Tapia-Abellán,
Kosta Cerović,
Lucija Kadunc,
Diego Angosto-Bazarra,
Pablo Pelegrin,
Roman Jerala

Affiliations

Iva Hafner-Bratkovič: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Petra Sušjan: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Duško Lainšček: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Ana Tapia-Abellán: Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, Carretera Buenavista s/n
Kosta Cerović: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Lucija Kadunc: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Diego Angosto-Bazarra: Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, Carretera Buenavista s/n
Pablo Pelegrin: Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, Carretera Buenavista s/n
Roman Jerala: Department of Synthetic Biology and Immunology, National Institute of Chemistry

DOI: https://doi.org/10.1038/s41467-018-07573-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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Activation of the NLRP3 inflammasome is associated with various diseases but its activation mechanism is not fully understood. Here, the authors determine the impact of different NLRP3 domains on sensing NLRP3 triggers, inflammasome assembly and regulation of NLRP3 inflammasome activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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