Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Myat Nyan; Daisuke Sato; Mitsumasa Oda; Tetsu Machida; Hiroshi Kobayashi; Takahiro Nakamura; Shohei Kasugai

Journal of Pharmacological Sciences (Jan 2007)

Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Myat Nyan,
Daisuke Sato,
Mitsumasa Oda,
Tetsu Machida,
Hiroshi Kobayashi,
Takahiro Nakamura,
Shohei Kasugai

Affiliations

Myat Nyan: Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Corresponding author. [email protected]
Daisuke Sato: Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
Mitsumasa Oda: Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
Tetsu Machida: Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
Hiroshi Kobayashi: Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
Takahiro Nakamura: Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
Shohei Kasugai: Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan

Journal volume & issue: Vol. 104, no. 4
pp. 384 – 386

Abstract

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Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response. Keywords:: simvastatin, calcium sulfate, bone formation

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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