Nature Communications (Oct 2017)
CCDC88B is required for pathogenesis of inflammatory bowel disease
- Nassima Fodil,
- Neda Moradin,
- Vicki Leung,
- Jean-Frederic Olivier,
- Irena Radovanovic,
- Thiviya Jeyakumar,
- Manuel Flores Molina,
- Ashley McFarquhar,
- Romain Cayrol,
- Dominique Bozec,
- Naglaa H. Shoukry,
- Michiaki Kubo,
- Julia Dimitrieva,
- Edouard Louis,
- Emilie Theatre,
- Stephanie Dahan,
- Yukihide Momozawa,
- Michel Georges,
- Garabet Yeretssian,
- Philippe Gros
Affiliations
- Nassima Fodil
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- Neda Moradin
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- Vicki Leung
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- Jean-Frederic Olivier
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- Irena Radovanovic
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- Thiviya Jeyakumar
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- Manuel Flores Molina
- Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), 900, Saint Denis Street, Pavillion R
- Ashley McFarquhar
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- Romain Cayrol
- Département de Pathologie et de Biologie Cellulaire de l’Université de Montréal, C.P. 6128, succ. Centre-ville
- Dominique Bozec
- Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Naglaa H. Shoukry
- Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), 900, Saint Denis Street, Pavillion R
- Michiaki Kubo
- Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN 1-7-22 Suehiro-cho, Tsurumi-ku
- Julia Dimitrieva
- Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l’Hôpital 1
- Edouard Louis
- Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l’Hôpital 1
- Emilie Theatre
- Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l’Hôpital 1
- Stephanie Dahan
- Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Yukihide Momozawa
- Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN 1-7-22 Suehiro-cho, Tsurumi-ku
- Michel Georges
- Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l’Hôpital 1
- Garabet Yeretssian
- Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Philippe Gros
- McGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade
- DOI
- https://doi.org/10.1038/s41467-017-01381-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Hook-related protein family member CCDC88b is encoded by a locus that has been associated with inflammatory bowel disease. Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer model, and detect high colonic levels of CCDC88b in patients with Crohn disease or ulcerative colitis, identifying that expression correlates with disease risk.
