Nature Communications (Jan 2021)
A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
- Shuai Zhao,
- Run Tian,
- Jun Wu,
- Shaoli Liu,
- Yuanning Wang,
- Meng Wen,
- Yingxu Shang,
- Qing Liu,
- Yan Li,
- Ying Guo,
- Zhaoran Wang,
- Ting Wang,
- Yujing Zhao,
- Huiru Zhao,
- Hui Cao,
- Yu Su,
- Jiashu Sun,
- Qiao Jiang,
- Baoquan Ding
Affiliations
- Shuai Zhao
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Run Tian
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Jun Wu
- Beijing Jishuitan Hospital, Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine
- Shaoli Liu
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Yuanning Wang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Meng Wen
- Beijing Jishuitan Hospital, Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine
- Yingxu Shang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Qing Liu
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Yan Li
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Ying Guo
- National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University
- Zhaoran Wang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Ting Wang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Yujing Zhao
- Beijing Jishuitan Hospital, Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine
- Huiru Zhao
- Beijing Jishuitan Hospital, Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine
- Hui Cao
- Beijing Jishuitan Hospital, Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine
- Yu Su
- Beijing Jishuitan Hospital, Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine
- Jiashu Sun
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Qiao Jiang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Baoquan Ding
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- DOI
- https://doi.org/10.1038/s41467-020-20638-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Safe haemodialysis is essential for patients with acute kidney injury and renal failure. Here the authors present a DNA origami-based approach with high affinity and specificity to thrombin, inhibiting coagulation.
