Nature Communications (Mar 2016)
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation
- Chuntao Zhao,
- Yaqi Deng,
- Lei Liu,
- Kun Yu,
- Liguo Zhang,
- Haibo Wang,
- Xuelian He,
- Jincheng Wang,
- Changqing Lu,
- Laiman N Wu,
- Qinjie Weng,
- Meng Mao,
- Jianrong Li,
- Johan H van Es,
- Mei Xin,
- Lee Parry,
- Steven A Goldman,
- Hans Clevers,
- Q. Richard Lu
Affiliations
- Chuntao Zhao
- Department of Pediatrics, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy
- Yaqi Deng
- Department of Pediatrics, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy
- Lei Liu
- Department of Pediatrics, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy
- Kun Yu
- Department of Pediatrics, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy
- Liguo Zhang
- Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Haibo Wang
- Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Xuelian He
- Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Jincheng Wang
- Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Changqing Lu
- Department of Pediatrics, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy
- Laiman N Wu
- Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Qinjie Weng
- Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University
- Meng Mao
- Key Laboratory of Obstetrics, and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy
- Jianrong Li
- Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843, USA
- Johan H van Es
- Hubrecht Institute, Uppsalalaan 8, Utrecht 3584CT, The Netherlands
- Mei Xin
- Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Lee Parry
- European Cancer Stem Cell Research Institute, Cardiff University
- Steven A Goldman
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Hans Clevers
- Hubrecht Institute, Uppsalalaan 8, Utrecht 3584CT, The Netherlands
- Q. Richard Lu
- Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- DOI
- https://doi.org/10.1038/ncomms10883
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Wnt/β-catenin signaling regulates oligodendrocyte (OL) development. Here the authors show that Tcf7l2, a β-catenin transcriptional partner,sequentially interacts with stage-specific partners to coordinate the transitions of differentiation initiation and maturation during OL development.
