Molbank (Aug 2023)
Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities
Abstract
Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate. The anticancer properties of the compounds were studied in vitro.
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