Molbank (Aug 2023)

Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities

  • Anna A. Smirnova,
  • Liana M. Zakirova,
  • Irina E. Smirnova,
  • Elena V. Tretyakova

DOI
https://doi.org/10.3390/M1707
Journal volume & issue
Vol. 2023, no. 3
p. M1707

Abstract

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Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate. The anticancer properties of the compounds were studied in vitro.

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