Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides

Abstract

ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synthesis of α-ADP-ribosylated peptides.