Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics

Orna Ernst; Mohd M. Khan; Benjamin L. Oyler; Sung Hwan Yoon; Jing Sun; Fang-Yu Lin; Nathan P. Manes; Alexander D. MacKerell; Iain D. C. Fraser; Robert K. Ernst; David R. Goodlett; Aleksandra Nita-Lazar

doi:10.1128/mSystems.00306-21

mSystems (Aug 2021)

Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics

Orna Ernst,
Mohd M. Khan,
Benjamin L. Oyler,
Sung Hwan Yoon,
Jing Sun,
Fang-Yu Lin,
Nathan P. Manes,
Alexander D. MacKerell,
Iain D. C. Fraser,
Robert K. Ernst,
David R. Goodlett,
Aleksandra Nita-Lazar

Affiliations

Orna Ernst: Signaling Systems Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Mohd M. Khan: Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Benjamin L. Oyler: School of Medicine, University of Maryland, Baltimore, Maryland, USA
Sung Hwan Yoon: Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Jing Sun: Signaling Systems Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Fang-Yu Lin: Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA
Nathan P. Manes: ORCiD; Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Alexander D. MacKerell: Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA
Iain D. C. Fraser: Signaling Systems Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Robert K. Ernst: ORCiD; Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA
David R. Goodlett: Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA
Aleksandra Nita-Lazar: ORCiD; Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

DOI: https://doi.org/10.1128/mSystems.00306-21
Journal volume & issue: Vol. 6, no. 4

Abstract

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Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage. This response is facilitated by specific receptors on the cell surface and intracellularly.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

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