Nature Communications (Nov 2016)
Vasculogenic mimicry in small cell lung cancer
- Stuart C. Williamson,
- Robert L. Metcalf,
- Francesca Trapani,
- Sumitra Mohan,
- Jenny Antonello,
- Benjamin Abbott,
- Hui Sun Leong,
- Christopher P. E. Chester,
- Nicole Simms,
- Radoslaw Polanski,
- Daisuke Nonaka,
- Lynsey Priest,
- Alberto Fusi,
- Fredrika Carlsson,
- Anders Carlsson,
- Mary J. C. Hendrix,
- Richard E. B. Seftor,
- Elisabeth A. Seftor,
- Dominic G. Rothwell,
- Andrew Hughes,
- James Hicks,
- Crispin Miller,
- Peter Kuhn,
- Ged Brady,
- Kathryn L. Simpson,
- Fiona H. Blackhall,
- Caroline Dive
Affiliations
- Stuart C. Williamson
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Robert L. Metcalf
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Francesca Trapani
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Sumitra Mohan
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Jenny Antonello
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Benjamin Abbott
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Hui Sun Leong
- Computational Biology Support Team, Cancer Research UK Manchester Institute
- Christopher P. E. Chester
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Nicole Simms
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Radoslaw Polanski
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Daisuke Nonaka
- The Christie NHS Foundation Trust
- Lynsey Priest
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Alberto Fusi
- The Christie NHS Foundation Trust
- Fredrika Carlsson
- University of Southern California Dornsife
- Anders Carlsson
- University of Southern California Dornsife
- Mary J. C. Hendrix
- Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Richard E. B. Seftor
- Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Elisabeth A. Seftor
- Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Dominic G. Rothwell
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Andrew Hughes
- The Institute of Cancer Sciences, University of Manchester
- James Hicks
- University of Southern California Dornsife
- Crispin Miller
- RNA Biology Group, Cancer Research UK Manchester Institute
- Peter Kuhn
- University of Southern California Dornsife
- Ged Brady
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Kathryn L. Simpson
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- Fiona H. Blackhall
- The Christie NHS Foundation Trust
- Caroline Dive
- Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
- DOI
- https://doi.org/10.1038/ncomms13322
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy.
