Positioning Transclival Tumor-Treating Fields for the Treatment of Diffuse Intrinsic Pontine Gliomas

Walid Ibn Essayed; Casey A. Jarvis; Joshua D. Bernstock; Anna Slingerland; John Albanese; Gregory K. Friedman; Omar Arnaout; Lissa Baird

doi:10.3390/life13030601

Life (Feb 2023)

Positioning Transclival Tumor-Treating Fields for the Treatment of Diffuse Intrinsic Pontine Gliomas

Walid Ibn Essayed,
Casey A. Jarvis,
Joshua D. Bernstock,
Anna Slingerland,
John Albanese,
Gregory K. Friedman,
Omar Arnaout,
Lissa Baird

Affiliations

Walid Ibn Essayed: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Casey A. Jarvis: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Joshua D. Bernstock: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Anna Slingerland: Department of Neurosurgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02144, USA
John Albanese: Department of Neurosurgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02144, USA
Gregory K. Friedman: Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Omar Arnaout: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lissa Baird: Department of Neurosurgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02144, USA

DOI: https://doi.org/10.3390/life13030601
Journal volume & issue: Vol. 13, no. 3
p. 601

Abstract

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Diffuse intrinsic pontine glioma (DIPG) carries an extremely poor prognosis, with 2-year survival rates of 2 = 0.568, p = 0.005 *; R2 = 0.605, p = 0.0002 *). Critically, neither of these parameters represent limitations to the implantation of a device within the dimensions of those currently available. Our findings confirm that the anatomy present within this age group is amenable to the placement of a 2 × 1 cm electrode array in 94% of patients examined. Our work serves to demonstrate the feasibility of implantable transclival devices for the provision of TTFs as a novel adjunctive therapy for DIPG.

Published in Life

ISSN: 2075-1729 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science
Website: http://www.mdpi.com/journal/life

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