Composite pheochromocytoma-ganglioneuroma of the adrenal gland: A case report with immunohistochemical study

Abstract

Composite tumors of the adrenal medulla consisting of pheochromocytoma and ganglioneuroma are rare tumors accounting for less than 3% of all sympathoadrenal tumors. These tumors display more than one line of differentiation in which normal and neoplastic chromaffin cells are capable of differentiating into ganglion cells under the influence of nerve growth factors. To the best of our knowledge, we report the second case with a composite tumor of the adrenal medulla in a normotensive patient from India.

Keywords

• Composite adrenal medullary tumor
• ganglioneuroma
• immunohistochemistry
• pheochromocytoma