Transcribed Ultraconserved Regions in Cancer

Myron K. Gibert; Aditya Sarkar; Bilhan Chagari; Christian Roig-Laboy; Shekhar Saha; Sylwia Bednarek; Benjamin Kefas; Farina Hanif; Kadie Hudson; Collin Dube; Ying Zhang; Roger Abounader

doi:10.3390/cells11101684

Cells (May 2022)

Transcribed Ultraconserved Regions in Cancer

Myron K. Gibert,
Aditya Sarkar,
Bilhan Chagari,
Christian Roig-Laboy,
Shekhar Saha,
Sylwia Bednarek,
Benjamin Kefas,
Farina Hanif,
Kadie Hudson,
Collin Dube,
Ying Zhang,
Roger Abounader

Affiliations

Myron K. Gibert: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Aditya Sarkar: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Bilhan Chagari: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Christian Roig-Laboy: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Shekhar Saha: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Sylwia Bednarek: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Benjamin Kefas: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Farina Hanif: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Kadie Hudson: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Collin Dube: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Ying Zhang: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Roger Abounader: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA

DOI: https://doi.org/10.3390/cells11101684
Journal volume & issue: Vol. 11, no. 10
p. 1684

Abstract

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Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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Abstract

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