Nature Communications (Aug 2020)
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
- Jonas Wilbs,
- Xu-Dong Kong,
- Simon J. Middendorp,
- Raja Prince,
- Alida Cooke,
- Caitlin T. Demarest,
- Mai M. Abdelhafez,
- Kalliope Roberts,
- Nao Umei,
- Patrick Gonschorek,
- Christina Lamers,
- Kaycie Deyle,
- Robert Rieben,
- Keith E. Cook,
- Anne Angelillo-Scherrer,
- Christian Heinis
Affiliations
- Jonas Wilbs
- Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
- Xu-Dong Kong
- Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
- Simon J. Middendorp
- Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
- Raja Prince
- Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern
- Alida Cooke
- Department of Biomedical Engineering, Carnegie Mellon University
- Caitlin T. Demarest
- Department of Biomedical Engineering, Carnegie Mellon University
- Mai M. Abdelhafez
- Department of Clinical Research, University of Bern
- Kalliope Roberts
- Department of Biomedical Engineering, Carnegie Mellon University
- Nao Umei
- Department of Biomedical Engineering, Carnegie Mellon University
- Patrick Gonschorek
- Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
- Christina Lamers
- Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
- Kaycie Deyle
- Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
- Robert Rieben
- Department of Clinical Research, University of Bern
- Keith E. Cook
- Department of Biomedical Engineering, Carnegie Mellon University
- Anne Angelillo-Scherrer
- Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern
- Christian Heinis
- Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
- DOI
- https://doi.org/10.1038/s41467-020-17648-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding.
