Терапевтический архив (Jul 2011)

Extremely high concentration of mexotrexate in blood serum leading to development of acute renal failure in a patient with acute lymphoblastic leukemia after high-dose consolidation

  • Mariya Anatol'evna Pimenova,
  • Andrey Nikolaevich Sokolov,
  • Lyudmila Semenovna Biryukova,
  • Elena Nikolaevna Ustinova,
  • Inna Ivanovna Shaforostova,
  • Irina Anatol'evna Donskova,
  • Rashit Fargatovich Bogdanov,
  • Elena Nikolaevna Parovichnikova,
  • Valeriy Grigor'evich Savchenko,
  • M A Pimenova,
  • A N Sokolov,
  • L S Biryukova,
  • E N Ustinova,
  • I I Shaforostova,
  • I A Donskova,
  • R F Bogdanov,
  • E N Parovichnikova,
  • V G Savchenko

Journal volume & issue
Vol. 83, no. 7
pp. 58 – 61

Abstract

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Acute renal failure (ARF) is one of rare and severe methotrexate(MT)-induced complications in patients with acute lymphoblastic leukemia. A case of MT-induced renal dysfunction with an extremely high serum MT concentration is reported. This toxicity required conduction of hemodiafiltration for extracorporeal MT elimination. The presence of homozygous mutation of methylene-tetrahydrofolate reductase reflects an individual metabolism of MT and its renal clearance.

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