Nature Communications (Feb 2016)
Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
- Ignacio Sancho-Martinez,
- Emmanuel Nivet,
- Yun Xia,
- Tomoaki Hishida,
- Aitor Aguirre,
- Alejandro Ocampo,
- Li Ma,
- Robert Morey,
- Marie N. Krause,
- Andreas Zembrzycki,
- Olaf Ansorge,
- Eric Vazquez-Ferrer,
- Ilir Dubova,
- Pradeep Reddy,
- David Lam,
- Yuriko Hishida,
- Min-Zu Wu,
- Concepcion Rodriguez Esteban,
- Dennis O’Leary,
- Geoffrey M. Wahl,
- Inder M. Verma,
- Louise C. Laurent,
- Juan Carlos Izpisua Belmonte
Affiliations
- Ignacio Sancho-Martinez
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Emmanuel Nivet
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Yun Xia
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Tomoaki Hishida
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Aitor Aguirre
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Alejandro Ocampo
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Li Ma
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Robert Morey
- Department of Reproductive Medicine, University of California, San Diego, Sanford Consortium for Regenerative Medicine
- Marie N. Krause
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Andreas Zembrzycki
- Molecular Neurobiology Laboratory, Salk Institute for Biological Studies
- Olaf Ansorge
- Department of Neuropathology, West Wing, Level 1, John Radcliffe Hospital
- Eric Vazquez-Ferrer
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Ilir Dubova
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Pradeep Reddy
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- David Lam
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Yuriko Hishida
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Min-Zu Wu
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Concepcion Rodriguez Esteban
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- Dennis O’Leary
- Molecular Neurobiology Laboratory, Salk Institute for Biological Studies
- Geoffrey M. Wahl
- Gene Expression Laboratory Wahl, Salk Institute for Biological Studies
- Inder M. Verma
- Laboratory of Genetics, Salk Institute for Biological Studies
- Louise C. Laurent
- Department of Reproductive Medicine, University of California, San Diego, Sanford Consortium for Regenerative Medicine
- Juan Carlos Izpisua Belmonte
- Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies
- DOI
- https://doi.org/10.1038/ncomms10743
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be subsequently transformed to glioma initiating cells that are able to the generate human glioma-like tumours in mice.
