PLoS Neglected Tropical Diseases (Jan 2024)

Development of a multivariate predictive model for dapsone adverse drug events in people with leprosy under standard WHO multidrug therapy.

  • Ana Carolina Galvão Dos Santos de Araujo,
  • Mariana de Andrea Vilas-Boas Hacker,
  • Roberta Olmo Pinheiro,
  • Ximena Illarramendi,
  • Sandra Maria Barbosa Durães,
  • Maurício Lisboa Nobre,
  • Milton Ozório Moraes,
  • Anna Maria Sales,
  • Gilberto Marcelo Sperandio da Silva

DOI
https://doi.org/10.1371/journal.pntd.0011901
Journal volume & issue
Vol. 18, no. 1
p. e0011901

Abstract

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BackgroundThe occurrence of adverse drug events (ADEs) during dapsone (DDS) treatment in patients with leprosy can constitute a significant barrier to the successful completion of the standardized therapeutic regimen for this disease. Well-known DDS-ADEs are hemolytic anemia, methemoglobinemia, hepatotoxicity, agranulocytosis, and hypersensitivity reactions. Identifying risk factors for ADEs before starting World Health Organization recommended standard multidrug therapy (WHO/MDT) can guide therapeutic planning for the patient. The objective of this study was to develop a predictive model for DDS-ADEs in patients with leprosy receiving standard WHO/MDT.MethodologyThis is a case-control study that involved the review of medical records of adult (≥18 years) patients registered at a Leprosy Reference Center in Rio de Janeiro, Brazil. The cohort included individuals that received standard WHO/MDT between January 2000 to December 2021. A prediction nomogram was developed by means of multivariable logistic regression (LR) using variables. The Hosmer-Lemeshow test was used to determine the model fit. Odds ratios (ORs) and their respective 95% confidence intervals (CIs) were estimated. The predictive ability of the LRM was assessed by the area under the receiver operating characteristic curve (AUC).ResultsA total of 329 medical records were assessed, comprising 120 cases and 209 controls. Based on the final LRM analysis, female sex (OR = 3.61; 95% CI: 2.03-6.59), multibacillary classification (OR = 2.5; 95% CI: 1.39-4.66), and higher education level (completed primary education) (OR = 1.97; 95% CI: 1.14-3.47) were considered factors to predict ADEs that caused standard WHO/MDT discontinuation. The prediction model developed had an AUC of 0.7208, that is 72% capable of predicting DDS-ADEs.ConclusionWe propose a clinical model that could become a helpful tool for physicians in predicting ADEs in DDS-treated leprosy patients.