EInvestigation of antiparkinsonian, anti-inflammatory and analgesic effects of ADK-1058, a metabolite of hemantane, in comparison with hemantane

Abstract

Antiparkinsonian, anti-inflammatory and analgesic activity of ADK-1058, a metabolite of hemantane, was investigated in comparison with hemantane at the effective dose of 20 mg/kg. ADK-1058 exhibits a minor antiparkinsonian effect by reducing the severity of oLigokinesia in C57BL/6 mice with MPTP-induced parkinsonian syndrome. ADK-1058 exhibits anti-inflammatory activity in the model of acetic acid peritonitis, but has no analgesic effect in visceral or somatic pain in mice. Effects of ADK-1058 at the dose of 20 mg/kg do not exceed antiparkinsonian, anti-inflammatory or analgesic effects of hemantane at the dose of 20 mg/kg.

Keywords

• метаболит гимантана
• паркинсонический синдром
• мфтп
• экссудативное воспаление
• висцеральная боль
• соматическая боль
• metabolite of hemantane
• experimental parkinsonian syndrome
• mptp
• exudative inflammation
• visceral pain
• somatic pain