Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner

Matthijs C. Dorst; Anna Tokarska; Ming Zhou; Kwang Lee; Stefanos Stagkourakis; Christian Broberger; Sotiris Masmanidis; Gilad Silberberg

doi:10.1038/s41467-020-18882-y

Nature Communications (Oct 2020)

Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner

Matthijs C. Dorst,
Anna Tokarska,
Ming Zhou,
Kwang Lee,
Stefanos Stagkourakis,
Christian Broberger,
Sotiris Masmanidis,
Gilad Silberberg

Affiliations

Matthijs C. Dorst: Department of Neuroscience, Karolinska Institutet
Anna Tokarska: Department of Neuroscience, Karolinska Institutet
Ming Zhou: Department of Neuroscience, Karolinska Institutet
Kwang Lee: Department of Neurobiology, University of California, Los Angeles
Stefanos Stagkourakis: Department of Neuroscience, Karolinska Institutet
Christian Broberger: Department of Neuroscience, Karolinska Institutet
Sotiris Masmanidis: Department of Neurobiology, University of California, Los Angeles
Gilad Silberberg: Department of Neuroscience, Karolinska Institutet

DOI: https://doi.org/10.1038/s41467-020-18882-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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The mechanisms underlying striatal cholinergic interneurons (ChINs) synchronization and its interaction with dopamine release are unclear. Here, the authors showed that polysynaptic inhibition between ChINs shapes their network activity and is mediated by dopaminergic input.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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