溶血磷脂酸在动脉粥样硬化病变中的作用 The Effects of Lysophosphatidic Acid in Atherosclerotic Lesion

Abstract

动脉粥样硬化是一种严重的慢性动脉炎症性疾病，可以引起冠状动脉粥样硬化性心脏病 和缺血性卒中等疾病。溶血磷脂酸在动脉粥样硬化的发生发展过程中起着至关重要的作用，它通过 对血管内皮细胞、血管平滑肌细胞、单核-巨噬细胞、成纤维细胞、树突状细胞、T淋巴细胞及血小板 等发挥作用促进动脉粥样硬化和血栓形成。探讨溶血磷脂酸在动脉粥样硬化发展中的作用和相关 病理生理机制有助于探索抗动脉粥样硬化的潜在药物和干预措施。 Abstract: Atherosclerosis is a severe and chronic inflammatory arterial disease that can lead to coronary heart disease, ischemic stroke and etc. Lysophosphatidic acid (LPA) plays a crucial role in the progression of atherosclerotic lesion by acting on endothelial cells, vascular smooth muscle cells, monocytes/macrophages, fibroblasts, dendritic cells, T-lymphocytes and platelets, which promotes atherosclerosis and thrombosis. Studies on the effects and pathophysiologic mechanisms of LPA in the atherosclerosis can contribute to find potential drugs and prevention measures for anti-atherosclerosis.

Keywords

• 溶血磷脂酸
• 动脉粥样硬化
• 血栓形成
• 内皮细胞
• lysophosphatidic acid
• atherosclerosis
• thrombosis
• endothelial cell