Nature Communications (May 2021)
Immunotranscriptomic profiling the acute and clearance phases of a human challenge dengue virus serotype 2 infection model
- John P. Hanley,
- Huy A. Tu,
- Julie A. Dragon,
- Dorothy M. Dickson,
- Roxana del Rio-Guerra,
- Scott W. Tighe,
- Korin M. Eckstrom,
- Nicholas Selig,
- Samuel V. Scarpino,
- Stephen S. Whitehead,
- Anna P. Durbin,
- Kristen K. Pierce,
- Beth D. Kirkpatrick,
- Donna M. Rizzo,
- Seth Frietze,
- Sean A. Diehl
Affiliations
- John P. Hanley
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- Huy A. Tu
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- Julie A. Dragon
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- Dorothy M. Dickson
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- Roxana del Rio-Guerra
- Flow Cytometry and Cell Sorting Facility, Department of Surgery, Larner College of Medicine, University of Vermont
- Scott W. Tighe
- Vermont Integrated Genomics Resource, University of Vermont
- Korin M. Eckstrom
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- Nicholas Selig
- Vaccine Testing Center, Larner College of Medicine, University of Vermont
- Samuel V. Scarpino
- Network Science Institute, Northeastern University
- Stephen S. Whitehead
- Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases
- Anna P. Durbin
- Center for Immunization Research, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University
- Kristen K. Pierce
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- Beth D. Kirkpatrick
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- Donna M. Rizzo
- Department of Civil and Environmental Engineering, College of Engineering and Mathematical Sciences, University of Vermont
- Seth Frietze
- Cellular and Molecular Biomedical Sciences Program, University of Vermont
- Sean A. Diehl
- Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont
- DOI
- https://doi.org/10.1038/s41467-021-22930-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Dengue virus causes a range of inflammatory pathology but understanding critical phases of the infection during human infection has been challenging. Here the author’s present immunotranscriptomic changes during the acute and clearance phases of a dengue virus serotype 2 human challenge model.
