Cell Stress (Nov 2018)

Regulation of T cell antitumor immune response by tumor induced metabolic stress

  • Fanny Chalmin,
  • Mélanie Bruchard,
  • Frederique Vegran,
  • Francois Ghiringhelli

DOI
https://doi.org/10.15698/cst2019.01.171
Journal volume & issue
Vol. 3, no. 1
pp. 9 – 18

Abstract

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Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor cells generate a particular metabolic environment in comparison to other tissues. Tumors are characterized by glycolysis, hypoxia, acidosis, amino acid depletion and fatty acid metabolism modification. Such metabolic changes promote tumor growth, impair immune response and lead to resistance to therapies. This review will detail how these modifications strongly affect CD8 and CD4 T cell functions and impact immunotherapy efficacy.

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