Nature Communications (Feb 2019)
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression
- Lara M. Myers,
- Michal Caspi Tal,
- Laughing Bear Torrez Dulgeroff,
- Aaron B. Carmody,
- Ronald J. Messer,
- Gunsagar Gulati,
- Ying Ying Yiu,
- Matthew M. Staron,
- Cesar Lopez Angel,
- Rahul Sinha,
- Maxim Markovic,
- Edward A. Pham,
- Benjamin Fram,
- Aijaz Ahmed,
- Aaron M. Newman,
- Jeffrey S. Glenn,
- Mark M. Davis,
- Susan M. Kaech,
- Irving L. Weissman,
- Kim J. Hasenkrug
Affiliations
- Lara M. Myers
- Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories
- Michal Caspi Tal
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Laughing Bear Torrez Dulgeroff
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Aaron B. Carmody
- Research Technologies Branch, Rocky Mountain Laboratories, NIAID, NIH
- Ronald J. Messer
- Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories
- Gunsagar Gulati
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Ying Ying Yiu
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Matthew M. Staron
- Research Technologies Branch, Rocky Mountain Laboratories, NIAID, NIH
- Cesar Lopez Angel
- Deparment of Immunology, Stanford University School of Medicine
- Rahul Sinha
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Maxim Markovic
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Edward A. Pham
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Benjamin Fram
- Department of Gastroenterology and Hepatology, Stanford University School of Medicine
- Aijaz Ahmed
- Department of Gastroenterology and Hepatology, Stanford University School of Medicine
- Aaron M. Newman
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Jeffrey S. Glenn
- Department of Gastroenterology and Hepatology, Stanford University School of Medicine
- Mark M. Davis
- Deparment of Microbiology and Immunology, Stanford University School of Medicine
- Susan M. Kaech
- Department of Immunobiology, Yale School of Medicine
- Irving L. Weissman
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Kim J. Hasenkrug
- Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories
- DOI
- https://doi.org/10.1038/s41467-019-08637-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection.
