Frontiers in Medicine (May 2022)
The BASDAI Cut-Off for Disease Activity Corresponding to the ASDAS Scores in a Taiwanese Cohort of Ankylosing Spondylitis
- Yi-Hsing Chen,
- Yi-Hsing Chen,
- Yi-Hsing Chen,
- Wen-Nan Huang,
- Wen-Nan Huang,
- Wen-Nan Huang,
- Yi-Ming Chen,
- Yi-Ming Chen,
- Yi-Ming Chen,
- Yi-Ming Chen,
- Kuo-Lung Lai,
- Kuo-Lung Lai,
- Tsu-Yi Hsieh,
- Tsu-Yi Hsieh,
- Tsu-Yi Hsieh,
- Tsu-Yi Hsieh,
- Wei-Ting Hung,
- Wei-Ting Hung,
- Wei-Ting Hung,
- Ching-Tsai Lin,
- Ching-Tsai Lin,
- Chih-Wei Tseng,
- Chih-Wei Tseng,
- Kuo-Tung Tang,
- Kuo-Tung Tang,
- Kuo-Tung Tang,
- Yin-Yi Chou,
- Yin-Yi Chou,
- Yi-Da Wu,
- Yi-Da Wu,
- Chin-Yin Huang,
- Chia-Wei Hsieh,
- Chia-Wei Hsieh,
- Chia-Wei Hsieh,
- Yen-Ju Chen,
- Yen-Ju Chen,
- Yen-Ju Chen,
- Yu-Wan Liao,
- Yu-Wan Liao,
- Hsin-Hua Chen,
- Hsin-Hua Chen,
- Hsin-Hua Chen,
- Hsin-Hua Chen,
- Hsin-Hua Chen,
- Hsin-Hua Chen,
- Hsin-Hua Chen
Affiliations
- Yi-Hsing Chen
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Yi-Hsing Chen
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Yi-Hsing Chen
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Wen-Nan Huang
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Wen-Nan Huang
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Wen-Nan Huang
- Department of Business Administration, Ling-Tung University, Taichung, Taiwan
- Yi-Ming Chen
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Yi-Ming Chen
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Yi-Ming Chen
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Yi-Ming Chen
- Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
- Kuo-Lung Lai
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Kuo-Lung Lai
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Tsu-Yi Hsieh
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Tsu-Yi Hsieh
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Tsu-Yi Hsieh
- Department of Medical Education, Taichung Veterans General Hospital, Taichung, Taiwan
- Tsu-Yi Hsieh
- PhD Program of Business, College of Business, Feng Chia University, Taichung, Taiwan
- Wei-Ting Hung
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Wei-Ting Hung
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Wei-Ting Hung
- Department of Medical Education, Taichung Veterans General Hospital, Taichung, Taiwan
- Ching-Tsai Lin
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Ching-Tsai Lin
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Chih-Wei Tseng
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Chih-Wei Tseng
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Kuo-Tung Tang
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Kuo-Tung Tang
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Kuo-Tung Tang
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Yin-Yi Chou
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Yin-Yi Chou
- Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan
- Yi-Da Wu
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Yi-Da Wu
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Chin-Yin Huang
- Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan
- Chia-Wei Hsieh
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Chia-Wei Hsieh
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Chia-Wei Hsieh
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Yen-Ju Chen
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Yen-Ju Chen
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Yen-Ju Chen
- Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
- Yu-Wan Liao
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Yu-Wan Liao
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Hsin-Hua Chen
- Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Hsin-Hua Chen
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Hsin-Hua Chen
- Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
- Hsin-Hua Chen
- Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan
- Hsin-Hua Chen
- Division of General Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- Hsin-Hua Chen
- 0Institute of Biomedical Science and Rong-Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, Taiwan
- Hsin-Hua Chen
- 1Institute of Public Health and Community Medicine Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan
- DOI
- https://doi.org/10.3389/fmed.2022.856654
- Journal volume & issue
-
Vol. 9
Abstract
ObjectivesThe Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) has been widely utilized to evaluate disease activity in patients with ankylosing spondylitis (AS) by an arbitrary cut-off of ≥4 to indicate high disease activity and initiate biological therapy. The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a new composite index to assess AS disease activity states that have been defined and validated. ASDAS ≥2.1 was selected as a criterion to start biological therapy. The purpose of this study was to estimate the corresponding BASDAI and ASDAS cut-off in a Taiwanese AS cohort.MethodsFrom November 2016 to October 2018, we assessed the ASDAS and the BASDAI regularly and recorded demographic data for 489 AS patients in Taichung Veterans General hospital (TCVGH) using an electronic patient-reported data system linked to electronic medical records. We used receiver operating characteristic curves with Youden's J statistic to determine the BASDAI values that correspond to ASDAS disease activity cut-offs (i.e., 1.3, 2.1, and 3.5).ResultsIn our population, the best trade-off BASDAI values corresponding to ASDAS -C-reactive protein (CRP) 1.3, 2.1, and 3.5 were 2.1, 3.1, and 3.7, respectively. The optimal BASDAI values corresponding to ASDAS-erythrocyte sedimentation rates 1.3, 2.1, and 3.5 were 2.0, 2.6, and 4.8, respectively.ConclusionWe propose a revised BASDAI cut-off based on our data, as BASDAI scores are commonly used globally. A more reasonable, lower BASDAI cut-off to initiate or change biological therapy will bring us closer to better decisions to treat AS patients.
Keywords
- ankylosing spondylitis
- biological therapy
- patient-reported outcome measures
- electronic medical records
- BASDAI score
- ASDAS
