Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Alessandro Cicconi; Rekha Rai; Xuexue Xiong; Cayla Broton; Amer Al-Hiyasat; Chunyi Hu; Siying Dong; Wenqi Sun; Jennifer Garbarino; Ranjit S. Bindra; Carl Schildkraut; Yong Chen; Sandy Chang

doi:10.1038/s41467-020-19674-0

Nature Communications (Nov 2020)

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Alessandro Cicconi,
Rekha Rai,
Xuexue Xiong,
Cayla Broton,
Amer Al-Hiyasat,
Chunyi Hu,
Siying Dong,
Wenqi Sun,
Jennifer Garbarino,
Ranjit S. Bindra,
Carl Schildkraut,
Yong Chen,
Sandy Chang

Affiliations

Alessandro Cicconi: Department of Laboratory Medicine, Yale University School of Medicine
Rekha Rai: Department of Laboratory Medicine, Yale University School of Medicine
Xuexue Xiong: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Cayla Broton: Department of Laboratory Medicine, Yale University School of Medicine
Amer Al-Hiyasat: Department of Laboratory Medicine, Yale University School of Medicine
Chunyi Hu: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Siying Dong: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Wenqi Sun: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Jennifer Garbarino: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine
Ranjit S. Bindra: Department of Therapeutic Radiology, Yale University School of Medicine
Carl Schildkraut: Department of Cell Biology, Albert Einstein College of Medicine
Yong Chen: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Sandy Chang: Department of Laboratory Medicine, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-19674-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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Primary microcephaly is a clinical feature of several human telomere disorder syndromes. Here the authors reveal a role of Microcephalin 1 in promoting telomere replication and repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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