Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

Jan Rossaint; Katharina Kühne; Jennifer Skupski; Hugo Van Aken; Mark R. Looney; Andres Hidalgo; Alexander Zarbock

doi:10.1038/ncomms13464

Nature Communications (Nov 2016)

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

Jan Rossaint,
Katharina Kühne,
Jennifer Skupski,
Hugo Van Aken,
Mark R. Looney,
Andres Hidalgo,
Alexander Zarbock

Affiliations

Jan Rossaint: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster
Katharina Kühne: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster
Jennifer Skupski: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster
Hugo Van Aken: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster
Mark R. Looney: Department of Medicine, University of California
Andres Hidalgo: Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
Alexander Zarbock: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster

DOI: https://doi.org/10.1038/ncomms13464
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Interaction between platelets and neutrophils promotes neutrophil activation. Here the authors show that neutrophils initiate the cross-talk with platelets by shuttling arachidonic acid via extracellular vesicles, which platelets convert to thromboxane A2that then elicits neutrophil activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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