Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

Abstract

Interaction between platelets and neutrophils promotes neutrophil activation. Here the authors show that neutrophils initiate the cross-talk with platelets by shuttling arachidonic acid via extracellular vesicles, which platelets convert to thromboxane A2that then elicits neutrophil activation.