Nature Communications (Oct 2019)
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
- Yu-Jie Li,
- Yu-Lu Cao,
- Jian-Xiong Feng,
- Yuanbo Qi,
- Shuxia Meng,
- Jie-Feng Yang,
- Ya-Ting Zhong,
- Sisi Kang,
- Xiaoxue Chen,
- Lan Lan,
- Li Luo,
- Bing Yu,
- Shoudeng Chen,
- David C. Chan,
- Junjie Hu,
- Song Gao
Affiliations
- Yu-Jie Li
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Yu-Lu Cao
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Jian-Xiong Feng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Yuanbo Qi
- Department of Genetics and Cell Biology, College of Life Sciences, Nankai University
- Shuxia Meng
- Division of Biology and Biological Engineering, California Institute of Technology
- Jie-Feng Yang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Ya-Ting Zhong
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Sisi Kang
- Department of Experimental Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth affiliated Hospital, Sun Yat-sen University
- Xiaoxue Chen
- Department of Experimental Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth affiliated Hospital, Sun Yat-sen University
- Lan Lan
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Li Luo
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Bing Yu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Shoudeng Chen
- Department of Experimental Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth affiliated Hospital, Sun Yat-sen University
- David C. Chan
- Division of Biology and Biological Engineering, California Institute of Technology
- Junjie Hu
- Department of Genetics and Cell Biology, College of Life Sciences, Nankai University
- Song Gao
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-019-12912-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.
