Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities

Jawhari Ahmed Hussain; Amri Nasser; Mukhrish Yousef E.; Gatri Rafik; Özdemir Ismail; Gürbüz Nevin; Mansour Lamjed; Koko Waleed S.; Hamdi Naceur

doi:10.1515/mgmc-2023-0008

Main Group Metal Chemistry (Nov 2023)

Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities

Jawhari Ahmed Hussain,
Amri Nasser,
Mukhrish Yousef E.,
Gatri Rafik,
Özdemir Ismail,
Gürbüz Nevin,
Mansour Lamjed,
Koko Waleed S.,
Hamdi Naceur

Affiliations

Jawhari Ahmed Hussain: Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan45142, Saudi Arabia
Amri Nasser: Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan45142, Saudi Arabia
Mukhrish Yousef E.: Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan45142, Saudi Arabia
Gatri Rafik: Laboratoire de Synthèse Organique Sélective et Hétérocyclique Évaluation Biologique LR17ES01 Faculté des Sciences de Tunis Faculté des Sciences de Tunis Campus Universitaire, Université de Tunis El Manar, 1092Tunis, Tunisia
Özdemir Ismail: İnönü University, Catalysis Research and Application Center, 44280Malatya, Turkey
Gürbüz Nevin: İnönü University, Catalysis Research and Application Center, 44280Malatya, Turkey
Mansour Lamjed: Zoology Department, College of Science, King Saud University, Saudi Arabia, P.O. Box 2455, Riyadh11451, Saudi Arabia
Koko Waleed S.: Department of Science Laboratories, College of Science and Arts, Qassim University, Ar Rass51921, Saudi Arabia
Hamdi Naceur: Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, Tunisia

DOI: https://doi.org/10.1515/mgmc-2023-0008
Journal volume & issue: Vol. 46, no. 1
pp. 1046 – 1049

Abstract

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A series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X2 (where X = halide) (3a–3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(ii) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 g·mL−1 and against tyrosinase with an IC50 of 20.77 and 25.84 g·mL−1, respectively. In addition, screening of benzimidazolium salts (2a–2d) and their ruthenium(ii) complexes (3a–3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines.

Published in Main Group Metal Chemistry

ISSN: 0792-1241 (Print); 2191-0219 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry
Website: https://www.degruyter.com/view/j/mgmc

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