PLoS ONE (Jan 2019)

Molecular characterization of low grade and high grade bladder cancer.

  • Alessandro Apollo,
  • Valerio Ortenzi,
  • Cristian Scatena,
  • Katia Zavaglia,
  • Paolo Aretini,
  • Francesca Lessi,
  • Sara Franceschi,
  • Sara Tomei,
  • Carlo Alberto Sepich,
  • Paolo Viacava,
  • Chiara Maria Mazzanti,
  • Antonio Giuseppe Naccarato

DOI
https://doi.org/10.1371/journal.pone.0210635
Journal volume & issue
Vol. 14, no. 1
p. e0210635

Abstract

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BackgroundBladder cancer (BC) is the 9th most common cancer diagnosis worldwide. Low grade (LG) represents 70% of all BCs, characterized by recurrence and rare ability (10-15%) to progress to high grade (HG) and invade. The remaining 30% is high grade (HG), fast invasive BC, which is resistant to therapy. Identifying biomarkers for predicting those tumors able to progress is a key goal for patient outcome improvement. This study focuses on the most promising prognostic markers.Materials and methodsTP53 and FGFR3 mutational status, Survivin, CK19, CK20, E-cadherin and CD44 gene expression analysis were performed on 66 BCs.ResultsSurvivin was found associated to tumor grade (pConclusionWe suggest Survivin, both as a biomarker associated to G3 BCs but negatively related to TP53 mutational status, and as a potential novel therapeutic target.