Unraveling the potential of nanozymes in the tapestry of orthopedic healing

Jiachen Yu; Hongyi Jiang; Hanting Shen; Liang Zhu; Xinghe Xue; Jian Lin; Jilong Wang; Xiaoyun Pan

Materials & Design (Jun 2024)

Unraveling the potential of nanozymes in the tapestry of orthopedic healing

Jiachen Yu,
Hongyi Jiang,
Hanting Shen,
Liang Zhu,
Xinghe Xue,
Jian Lin,
Jilong Wang,
Xiaoyun Pan

Affiliations

Jiachen Yu: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Hongyi Jiang: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Hanting Shen: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Liang Zhu: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Xinghe Xue: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Corresponding authors.
Jian Lin: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Corresponding authors.
Jilong Wang: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, People's Republic of China; Corresponding authors.
Xiaoyun Pan: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Corresponding authors.

Journal volume & issue: Vol. 242
p. 113016

Abstract

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Bone-related disorders, such as osteoporosis, osteoarthritis, and osteosarcoma, have complex origins. Genetic, environmental factors, and significantly, oxidative stress due to Reactive Oxygen Species (ROS) play pivotal roles in these disorders. With their profound implications on global health, it becomes imperative to seek innovative therapeutic solutions. Nanozymes, known for their superior stability, cost-effectiveness, and tunable properties, present themselves as a prospective answer in mitigating ROS-driven bone ailments. This review explores the diverse applications and mechanisms of nanozymes in the context of bone health. They show potential in not only counteracting ROS-induced oxidative stress but also in modulating angiogenesis and showcasing antibacterial effects. We systematically analyze the effects of nanozymes on conditions such as osteonecrosis of the femoral head, skin flap transplantation, osteomyelitis, osteoarthritis, intervertebral disc disease, osteoporosis, and osteosarcoma, highlighting their potential roles in modulating disease processes. In addition, we discuss the challenges of applying nanozymes to orthopedic diseases. It offers insights into the transformative potential of nanozymes in bone therapeutics, underscoring the need to address challenges and capitalize on opportunities for their broader application in orthopedics.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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